Roscoe Smith is the latest player to leave UConn.
Sources confirmed a CBSSports.com report that the 6-foot-8 sophomore forward from Baltimore had received a release to transfer.
He originally picked the Huskies over Duke and Georgetown.
Junior forward Alex Oriakhi has already transferred to Missouri, and redshirt freshman center Michael Bradley is also transferring.
Jeremy Lamb and Andre Drummond declared for the NBA Draft.
Oriakhi is eligible immediately, whereas the schools Smith and Bradley land at would have to apply for waivers to get them eligible.
UConn has one incoming recruit in New York City shooting guard Omar Calhoun and will also add Holy Cross transfer guard R.J. Evans.
Guards Shabazz Napier and Ryan Boatright are expected to return, along with frontcourt players DeAndre Daniels, Niels Giffey, Tyler Olander and Enosch Wolf.
The Huskies are in the market for 6-8 shot-blocker Chris Obekpa and 6-11 center Bradley Hayes, both 2012 late signees.